Pesquisa | BVS IEC

1.

Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.

Hoeper, Marius M; Badesch, David B; Ghofrani, H Ardeschir; Gibbs, J Simon R; Gomberg-Maitland, Mardi; McLaughlin, Vallerie V; Preston, Ioana R; Souza, Rogerio; Waxman, Aaron B; Grünig, Ekkehard; Kopec, Grzegorz; Meyer, Gisela; Olsson, Karen M; Rosenkranz, Stephan; Xu, Yayun; Miller, Barry; Fowler, Marcie; Butler, John; Koglin, Joerg; de Oliveira Pena, Janethe; Humbert, Marc.

N Engl J Med ; 388(16): 1478-1490, 2023 Apr 20.

Artigo em Inglês | MEDLINE | ID: mdl-36877098

2.

Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study.

Jackson, David J; Heaney, Liam G; Humbert, Marc; Kent, Brian D; Shavit, Anat; Hiljemark, Lina; Olinger, Lynda; Cohen, David; Menzies-Gow, Andrew; Korn, Stephanie.

Lancet ; 403(10423): 271-281, 2024 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-38071986

3.

Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome.

Robert, Fabien; Certain, Marie-Caroline; Baron, Audrey; Thuillet, Raphaël; Duhaut, Léa; Ottaviani, Mina; Kamel Chelgham, Mustapha; Normand, Corinne; Berrebeh, Nihel; Ricard, Nicolas; Furlan, Valerie; Desroches-Castan, Agnès; Gonzales, Emmanuel; Jacquemin, Emmanuel; Sitbon, Olivier; Humbert, Marc; Bailly, Sabine; Coilly, Audrey; Guignabert, Christophe; Tu, Ly; Savale, Laurent.

Am J Respir Crit Care Med ; 2024 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-38626313

4.

Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction.

Le Ribeuz, Hélène; Saint-Martin Willer, Anaïs; Chevalier, Benoit; Sancho, Maria; Masson, Bastien; Eyries, Mélanie; Jung, Vincent; Guerrera, Ida Chiara; Dutheil, Mary; El Jekmek, Kristelle; Laubry, Loann; Carpentier, Gilles; Perez-Vizcaino, Francisco; Tu, Ly; Guignabert, Christophe; Chaumais, Marie-Camille; Péchoux, Christine; Humbert, Marc; Hinzpeter, Alexandre; Mercier, Olaf; Capuano, Véronique; Montani, David; Antigny, Fabrice.

Am J Respir Cell Mol Biol ; 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38546978

5.

Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.

Guignabert, Christophe; Savale, Laurent; Boucly, Athénaïs; Thuillet, Raphaël; Tu, Ly; Ottaviani, Mina; Rhodes, Christopher J; De Groote, Pascal; Prévot, Grégoire; Bergot, Emmanuel; Bourdin, Arnaud; Howard, Luke S; Fadel, Elie; Beurnier, Antoine; Roche, Anne; Jevnikar, Mitja; Jaïs, Xavier; Montani, David; Wilkins, Martin R; Sitbon, Olivier; Humbert, Marc.

Circulation ; 147(24): 1809-1822, 2023 06 13.

Artigo em Inglês | MEDLINE | ID: mdl-37096577

6.

Sotatercept for the Treatment of Pulmonary Arterial Hypertension.

Humbert, Marc; McLaughlin, Vallerie; Gibbs, J Simon R; Gomberg-Maitland, Mardi; Hoeper, Marius M; Preston, Ioana R; Souza, Rogerio; Waxman, Aaron; Escribano Subias, Pilar; Feldman, Jeremy; Meyer, Gisela; Montani, David; Olsson, Karen M; Manimaran, Solaiappan; Barnes, Jennifer; Linde, Peter G; de Oliveira Pena, Janethe; Badesch, David B.

N Engl J Med ; 384(13): 1204-1215, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33789009

7.

Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors.

Grynblat, Julien; Khouri, Charles; Hlavaty, Alex; Jais, Xavier; Savale, Laurent; Camille Chaumais, Marie; Kularatne, Mithum; Jevnikar, Mitja; Boucly, Athénaïs; Antigny, Fabrice; Perros, Frédéric; Simonneau, Gérald; Sitbon, Olivier; Humbert, Marc; Montani, David.

Eur Respir J ; 2024 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-38697649

8.

Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with pulmonary arterial hypertension.

Boucly, Athénaïs; Beurnier, Antoine; Turquier, Ségolène; Jevnikar, Mitja; de Groote, Pascal; Chaouat, Ari; Cheron, Céline; Jaïs, Xavier; Picard, François; Prévot, Grégoire; Roche, Anne; Solinas, Sabina; Cottin, Vincent; Bauer, Fabrice; Montani, David; Humbert, Marc; Savale, Laurent; Sitbon, Olivier.

Eur Respir J ; 2024 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-38663975

9.

Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: an international multicentre study.

Grynblat, Julien; Bogaard, Harm Jan; Eyries, Mélanie; Meyrignac, Olivier; Savale, Laurent; Jaïs, Xavier; Ghigna, Maria-Rosa; Celant, Lucas; Meijboom, Lilian; Houweling, Arjan C; Levy, Marilyne; Antigny, Fabrice; Chaouat, Ari; Cottin, Vincent; Guignabert, Christophe; Coulet, Florence; Sitbon, Olivier; Bonnet, Damien; Humbert, Marc; Montani, David.

Eur Respir J ; 63(4)2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38514094

10.

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.

Masson, Bastien; Le Ribeuz, Hélène; Sabourin, Jessica; Laubry, Loann; Woodhouse, Emily; Foster, Richard; Ruchon, Yann; Dutheil, Mary; Boët, Angèle; Ghigna, Maria-Rosa; De Montpreville, Vincent Thomas; Mercier, Olaf; Beech, David J; Benitah, Jean-Pierre; Bailey, Marc A; Humbert, Marc; Montani, David; Capuano, Véronique; Antigny, Fabrice.

Circ Res ; 131(9): e102-e119, 2022 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-36164973

11.

Pulmonary Hypertension in Connective Tissue Diseases Other than Systemic Sclerosis.

Budhram, Brandon; Weatherald, Jason; Humbert, Marc.

Semin Respir Crit Care Med ; 2024 Mar 18.

Artigo em Inglês | MEDLINE | ID: mdl-38499196

12.

Clinical Phenotype and Outcomes of Pulmonary Hypertension Associated with Myeloproliferative Neoplasms: A Population-based Study.

Montani, David; Thoré, Pierre; Mignard, Xavier; Jaïs, Xavier; Boucly, Athénaïs; Jevnikar, Mitja; Seferian, Andrei; Jutant, Etienne-Marie; Cottin, Vincent; Fadel, Elie; Simonneau, Gérald; Savale, Laurent; Sitbon, Olivier; Humbert, Marc.

Am J Respir Crit Care Med ; 208(5): 600-612, 2023 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-37311222

13.

Differential Diagnosis of Suspected Chronic Obstructive Pulmonary Disease Exacerbations in the Acute Care Setting: Best Practice.

Celli, Bartolome R; Fabbri, Leonardo M; Aaron, Shawn D; Agusti, Alvar; Brook, Robert D; Criner, Gerard J; Franssen, Frits M E; Humbert, Marc; Hurst, John R; Montes de Oca, Maria; Pantoni, Leonardo; Papi, Alberto; Rodriguez-Roisin, Roberto; Sethi, Sanjay; Stolz, Daiana; Torres, Antoni; Vogelmeier, Claus F; Wedzicha, Jadwiga A.

Am J Respir Crit Care Med ; 207(9): 1134-1144, 2023 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-36701677

14.

Contribution of transient receptor potential canonical channels in human and experimental pulmonary arterial hypertension.

Masson, Bastien; Saint-Martin Willer, Anais; Dutheil, Mary; Penalva, Lucille; Le Ribeuz, Hélène; El Jekmek, Kristelle; Ruchon, Yann; Cohen-Kaminsky, Sylvia; Sabourin, Jessica; Humbert, Marc; Mercier, Olaf; Montani, David; Capuano, Véronique; Antigny, Fabrice.

Am J Physiol Lung Cell Mol Physiol ; 325(2): L246-L261, 2023 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-37366608

15.

The evolving landscape of pulmonary arterial hypertension clinical trials.

Weatherald, Jason; Boucly, Athénaïs; Peters, Anthony; Montani, David; Prasad, Krishna; Psotka, Mitchell A; Zannad, Faiez; Gomberg-Maitland, Mardi; McLaughlin, Vallerie; Simonneau, Gérald; Humbert, Marc.

Lancet ; 400(10366): 1884-1898, 2022 11 26.

Artigo em Inglês | MEDLINE | ID: mdl-36436527

16.

Cytokines as prognostic biomarkers in pulmonary arterial hypertension.

Boucly, Athénaïs; Tu, Ly; Guignabert, Christophe; Rhodes, Christopher; De Groote, Pascal; Prévot, Grégoire; Bergot, Emmanuel; Bourdin, Arnaud; Beurnier, Antoine; Roche, Anne; Jevnikar, Mitja; Jaïs, Xavier; Montani, David; Wilkins, Martin R; Humbert, Marc; Sitbon, Olivier; Savale, Laurent.

Eur Respir J ; 61(3)2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36549710

17.

Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension.

Humbert, Marc; McLaughlin, Vallerie; Gibbs, J Simon R; Gomberg-Maitland, Mardi; Hoeper, Marius M; Preston, Ioana R; Souza, Rogerio; Waxman, Aaron B; Ghofrani, Hossein-Ardeschir; Escribano Subias, Pilar; Feldman, Jeremy; Meyer, Gisela; Montani, David; Olsson, Karen M; Manimaran, Solaiappan; de Oliveira Pena, Janethe; Badesch, David B.

Eur Respir J ; 61(1)2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36041750

18.

Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial.

Souza, Rogerio; Badesch, David B; Ghofrani, H Ardeschir; Gibbs, J Simon R; Gomberg-Maitland, Mardi; McLaughlin, Vallerie V; Preston, Ioana R; Waxman, Aaron B; Grünig, Ekkehard; Kopec, Grzegorz; Meyer, Gisela; Olsson, Karen M; Rosenkranz, Stephan; Lin, Jianxin; Johnson-Levonas, Amy O; de Oliveira Pena, Janethe; Humbert, Marc; Hoeper, Marius M.

Eur Respir J ; 62(3)2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37696565

19.

Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis.

Sanges, Sébastien; Rice, Lisa; Tu, Ly; Valenzi, Eleanor; Cracowski, Jean-Luc; Montani, David; Mantero, Julio C; Ternynck, Camille; Marot, Guillemette; Bujor, Andreea M; Hachulla, Eric; Launay, David; Humbert, Marc; Guignabert, Christophe; Lafyatis, Robert.

Ann Rheum Dis ; 82(3): 365-373, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36600187

20.

In-depth characterization of pulmonary arterial hypertension in mixed connective tissue disease: a French national multicentre study.

Chaigne, Benjamin; Chevalier, Kevin; Boucly, Athenaïs; Agard, Christian; Baudet, Antoine; Bourdin, Arnaud; Chabanne, Céline; Cottin, Vincent; Fesler, Pierre; Goupil, François; Jego, Patrick; Launay, David; Lévesque, Hervé; Maurac, Arnaud; Mohamed, Shirine; Tromeur, Cécile; Rottat, Laurence; Sitbon, Olivier; Humbert, Marc; Mouthon, Luc.

Rheumatology (Oxford) ; 62(10): 3261-3267, 2023 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-36727465

BVS IEC

Instituto Evandro Chagas

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